Epidemiology of invasive fungal diseases among patients with haematological disorders in the Asia-Pacific: a prospective observational study
Journal
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Journal Volume
21
Journal Issue
6
Pages
594.e7
Date Issued
2015-06
Author(s)
Hsu, L Y
Lee, D G
Yeh, S P
Bhurani, D
Khanh, B Q
Low, C Y
Norasetthada, L
Chan, T
Kwong, Y L
Vaid, A K
Alejandria, I
Mendoza, M
Johnson, A
Tan, T Y
Abstract
We conducted a 2-year multicentre prospective observational study to determine the epidemiology of and mortality associated with invasive fungal diseases (IFDs) among patients with haematological disorders in Asia. Eleven institutions from 8 countries/regions participated, with 412 subjects (28.2% possible, 38.3% probable and 33.5% proven IFDs) recruited. The epidemiology of IFDs in participating institutions was similar to Western centres, with Aspergillus spp. (65.9%) or Candida spp. (26.7%) causing the majority of probable and proven IFDs. The overall 30-day mortality was 22.1%. Progressive haematological disorder (odds ratio [OR] 5.192), invasive candidiasis (OR 3.679), and chronic renal disease (OR 6.677) were independently associated with mortality.
Subjects
Antifungal agents; Asia-Pacific; epidemiology; haematological diseases; invasive fungal disease
SDGs
Type
journal article