https://scholars.lib.ntu.edu.tw/handle/123456789/631973
標題: | Constrictive bronchiolitis obliterans with a presumptive etiology of preceding feline herpesvirus infection in a cat | 作者: | Hsieh, Pin I. HUI-WEN CHEN Yeh, Hsiao Ning Lam, Man Cham Lo, Pei Ying WEI-HSIANG HUANG Shih, Cheng Hsin Lin, Chung Hui |
關鍵字: | Bronchiolar disorders; Bronchoalveolar lavage; Cat; Constrictive bronchiolitis obliterans; Feline herpesvirus; Lung high-resolution computed tomography; Respiratory disease | 公開日期: | 1-十二月-2022 | 出版社: | BMC | 卷: | 18 | 期: | 1 | 來源出版物: | BMC Veterinary Research | 摘要: | Background: Bronchiolar disorders are rarely recognized in cats. Constrictive bronchiolitis obliterans is characterized by concentric peribronchiolar fibrosis and inflammation of the bronchioles, but the underlying causes remain poorly understood in current small animal medicine. Case presentation: A 9-year-old cat presented with paroxysmal tachypnea, infrequent cough and persistent labor breathing. Thoracic radiography showed lung hyperinflation and bronchointerstitial pattern, and pulmonary function assessment revealed flow limitation in the late-expiratory phase and poor response to short-acting bronchodilator. Dorsally distributed subpleural ground glass opacities with distinct margin and tree-in-bud opacities were observed on lung high-resolution computed tomography. The cat underwent bronchoalveolar lavage (BAL) and showed severe neutrophilic inflammation. Feline herpesvirus was the only pathogen detected in the BAL fluid. Multiple therapeutic attempts were unsuccessful and the cat died 8 weeks after the initial presentation. Necropsy revealed the infiltration of inflammatory cells, obstruction of the bronchiolar lumen, and submucosal concentric fibrosis suggesting constrictive bronchiolitis obliterans. Combining the pre- and post-mortem findings, as well as the time from symptom onset or BAL to necropsy, constrictive bronchiolitis obliterans was possibly triggered by a preceding feline herpesvirus infection in this case. Conclusions: The history of nonvaccinated status, lower airway neutrophilic inflammation, and presence of feline herpesvirus in the BAL fluid without coexistence of other pathogens led to the presumption that constrictive bronchiolitis obliterans was induced by a preceding feline herpesvirus infection in this cat. The pathological changes of bronchiolitis obliterans induced by a preceding feline herpesvirus infection could be different from that of cats with acute herpesvirus pneumonia, such as intranuclear inclusions would disappear over time and were no longer found 7–10 days after inoculation. The presence of patchy distribution of subpleural ground glass opacities on lung high-resolution computed tomography should raise the suspicion of peribronchiolar fibrosis. Clinical awareness of bronchiolar disorders as a differential diagnosis is important in cats with lung hyperinflation and labored breathing who show poor reversibility to bronchodilator. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133345474&doi=10.1186%2fs12917-022-03368-4&partnerID=40&md5=878b052c494478996ca5f0bb697c8658 https://scholars.lib.ntu.edu.tw/handle/123456789/631973 |
ISSN: | 1746-6148 | DOI: | 10.1186/s12917-022-03368-4 |
顯示於: | 獸醫學系 |
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