https://scholars.lib.ntu.edu.tw/handle/123456789/631988
標題: | Splenic Arterial Pulsatility Index to Predict Hepatic Fibrosis in Hemodialysis Patients with Chronic Hepatitis C Virus Infection | 作者: | CHEN-HUA LIU YU-JEN FANG CHUN-JEN LIU TUNG-HUNG SU SHANG-CHIN HUANG TAI-CHUNG TSENG Wu, Jo-Hsuan PEI-JER CHEN JIA-HORNG KAO |
關鍵字: | duplex Doppler ultrasonography; hepatic fibrosis; hepatitis C virus; liver stiffness; noninvasive diagnosis; splenic arterial pulsatility index; transient elastography | 公開日期: | 3-三月-2023 | 出版社: | MDPI | 卷: | 12 | 期: | 5 | 起(迄)頁: | 2020 | 來源出版物: | Journal of clinical medicine | 摘要: | The clinical utility of the splenic arterial pulsatility index (SAPI), a duplex Doppler ultrasonographic index, to predict the stage of hepatic fibrosis in hemodialysis patients with chronic hepatitis C virus (HCV) infection remains elusive. We conducted a retrospective, cross-sectional study to include 296 hemodialysis patients with HCV who underwent SAPI assessment and liver stiffness measurements (LSMs). The levels of SAPI were significantly associated with LSMs (Pearson correlation coefficient: 0.413, p < 0.001) and different stages of hepatic fibrosis as determined using LSMs (Spearman's rank correlation coefficient: 0.529, p < 0.001). The areas under receiver operating characteristics (AUROCs) of SAPI to predict the severity of hepatic fibrosis were 0.730 (95% CI: 0.671-0.789) for ≥F1, 0.782 (95% CI: 0.730-0.834) for ≥F2, 0.838 (95% CI: 0.781-0.894) for ≥F3, and 0.851 (95% CI: 0.771-0.931) for F4. Furthermore, the AUROCs of SAPI were comparable to those of the fibrosis index based on four parameters (FIB-4) and superior to those of the aspartate transaminase (AST)-to-platelet ratio index (APRI). The positive predictive value (PPV) for ≥F1 was 79.5% when the Youden index was set at 1.04, and the negative predictive values (NPVs) for ≥F2, ≥F3, and F4 were 79.8%, 92,6%, and 96.9%, respectively, when the maximal Youden indices were set at 1.06, 1.19, and 1.30. The diagnostic accuracies of SAPI with the maximal Youden index for a fibrosis stage of ≥F1, ≥F2, ≥F3, and F4 were 69.6%, 67.2%, 75.0%, and 85.1%, respectively. In conclusion, SAPI can serve as a good noninvasive index in predicting the severity of hepatic fibrosis in hemodialysis patients with chronic HCV infection. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/631988 | ISSN: | 2077-0383 | DOI: | 10.3390/jcm12052020 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。