https://scholars.lib.ntu.edu.tw/handle/123456789/632035
標題: | Ultrasonic interfacial crosslinking of TiO2-based nanocomposite hydrogels through thiol-norbornene reactions for sonodynamic antibacterial treatment | 作者: | Yang, Su Rung WANG, R. Yan, Chen Jie Lin, Yi Yun Yeh, Yu Jia Yeh, Ying Yu YI-CHEUN YEH |
關鍵字: | TIO2 NANOPARTICLES; STAPHYLOCOCCUS-AUREUS; SUPEROXIDE ANION; THERAPY; GROWTH; SONOCHEMISTRY; DEGRADATION; MEMBRANE; OXYGEN; SOUND | 公開日期: | 1-一月-2023 | 出版社: | ROYAL SOC CHEMISTRY | 來源出版物: | Biomaterials Science | 摘要: | Nanocomposite (NC) hydrogels used for sonodynamic therapy (SDT) face challenges such as lacking interfacial interactions between the polymers and nanomaterials as well as presenting uneven dispersion of nanomaterials in the hydrogel network, reducing their mechanical properties and treatment efficiency. Here, we demonstrate a promising approach of co-engineering nanomaterials and interfacial crosslinking to expand the materials construction and biomedical applications of NC hydrogels in SDT. In this work, mesoporous silica-coated titanium dioxide nanoparticles with thiolated surface functionalization (TiO2@MS-SH) are utilized as crosslinkers to react with norbornene-functionalized dextran (Nor-Dex) through ultrasound-triggered thiol-norbornene reactions, forming TiO2@MS-SH/Nor-Dex NC hydrogels. The TiO2@MS-SH nanoparticles act not only as multivalent crosslinkers to improve the mechanical properties of hydrogels under ultrasound irradiation but also as reactive oxygen species (ROS) generators to allow the use of TiO2@MS-SH/Nor-Dex NC hydrogels in SDT applications. Particularly, the TiO2@MS-SH/Nor-Dex NC hydrogels present tailorable microstructures, properties, and sonodynamic killing of bacteria through the modulation of the ultrasound frequency. Taken together, a versatile TiO2-based NC hydrogel platform prepared under ultrasonic interfacial crosslinking reactions is developed for advancing the applications in SDT. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/632035 | ISSN: | 20474830 | DOI: | 10.1039/d2bm01950g |
顯示於: | 高分子科學與工程學研究所 |
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