https://scholars.lib.ntu.edu.tw/handle/123456789/632368
Title: | Effect of physical activity in a weight loss program on circulating total ANGPTL8 concentrations in northern Americans with obesity: A prospective randomized controlled trial | Authors: | Fu C.-P Oczypok E.E Ali H DeLany J.P Reeves V.L RUEY-FENG CHANG Kershaw E.E. |
Keywords: | ANGPTL8; Physical activity; Weight loss | Issue Date: | 2022 | Journal Volume: | 32 | Journal Issue: | 7 | Start page/Pages: | 1725-1733 | Source: | Nutrition, Metabolism and Cardiovascular Diseases | Abstract: | Background and aims: The primary goals of this study were to clarify 1) the effect of weight loss by lifestyle intervention on circulating total angiopoietin-like protein 8 (ANGPTL8), and 2) the role of physical activity on serum total ANGPTL8 in northern Americans with obesity but without diabetes. Methods and results: A total of 130 subjects with body mass index (BMI) ≧ 35 kg/m2 but without diabetes were recruited, and 121 subjects completed a weight loss program for data analysis. Abdominal adipose tissue was determined by non-contrast computed tomography (CT). Serum total ANGPTL8 was higher in the group with obesity than in the lean control group. Serum total ANGPTL8 was positively correlated with waist circumference (WC), BMI, fasting insulin, HOMA-IR, HOMA-B, QUICKI, hs-CRP, IL-6, and leptin. Serum total ANGPTL8 did not significantly differ between the two intervention groups at baseline, and it was significantly lower after weight loss, with comparable changes with diet only and diet plus physical activity. Conclusion: Among northern Americans with obesity but without diabetes, a lifestyle modification resulted in significant reduction of circulating total ANGPTL8 concentrations in a 6-month weight-loss period. Although addition of physical activity resulted in greater total and liver fat loss, it did not promote further significant decline of serum total ANGPTL8 beyond diet alone. © 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129697965&doi=10.1016%2fj.numecd.2022.04.006&partnerID=40&md5=5f011b37e3466703db42186aa5e2d744 https://scholars.lib.ntu.edu.tw/handle/123456789/632368 |
ISSN: | 9394753 | DOI: | 10.1016/j.numecd.2022.04.006 | SDG/Keyword: | adiponectin; alanine aminotransferase; angiopoietin like protein 8; C reactive protein; creatinine; hemoglobin A1c; high density lipoprotein; high density lipoprotein cholesterol; insulin; interleukin 2; interleukin 6; leptin; low density lipoprotein; low density lipoprotein cholesterol; peroxisome proliferator activated receptor gamma; triacylglycerol; very low density lipoprotein; angiopoietin related protein; ANGPTL8 protein, human; peptide hormone; adipose tissue; adult; Article; body composition; body weight loss; caloric intake; clinical article; controlled study; enzyme linked immunosorbent assay; fat mass; glucose blood level; glucose metabolism; homeostasis model assessment; human; insulin blood level; insulin sensitivity; leukocyte count; major clinical study; male; obesity; physical activity; plethysmography; Quantitative Insulin Sensitivity Check Index; randomized controlled trial; systolic blood pressure; body mass; exercise; obesity; prospective study; weight loss program; Angiopoietin-Like Protein 8; Angiopoietin-like Proteins; Body Mass Index; Exercise; Humans; Obesity; Peptide Hormones; Prospective Studies; Weight Loss; Weight Reduction Programs |
Appears in Collections: | 資訊工程學系 |
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