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  2. 生物資源暨農學院
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Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/632574
Title: Assessment of Brown and Beige Adipose Tissue Activation in Mice Using PET/CT Imaging
Authors: Chen, Yu-Jen
Liao, Pei Xin
WEN-HUNG KUO 
Chen, Ching Yi
SHIH-TORNG DING 
Wang, Mei Hui
Keywords: Beige adipose tissue; Brown adipose tissue; Cold-induced thermogenesis; PET/CT scintigraphy; Uncoupling protein 1 (UCP1)
Issue Date: 1-Jan-2023
Journal Volume: 2662
Start page/Pages: 135 - 145
Source: Methods in Molecular Biology
Abstract: 
In response to cold induction, brown adipose tissues (BAT) and emerged brown-like adipocytes (beige adipocytes) in subcutaneous white adipose tissues (WAT browning/beiging) are activated. Thermogenesis is increased during glucose and fatty acid uptake and metabolism in adult humans and mice. This activation of BAT or WAT beiging to generate heat helps to counteract diet-induced obesity. This protocol applies the glucose analog radiotracer 18F-fluorodeoxyglucose (FDG), coupled with positron emission tomography and computed tomography (PET/CT) scanning to evaluate cold-induced thermogenesis in the active BAT (interscapular region) and browned/beiged WAT (subcutaneous adipose region) in mice. The PET/CT scanning technique not only can quantify cold-induced glucose uptake in well-known BAT and beige-fat depots but also helps to visualize the anatomical location of novel uncharacterized mouse BAT and beige fat where cold-induced glucose uptake is high. Histological analysis is further employed to validate signals of delineated anatomical regions in PET/CT images as bona fide mouse BAT or beiged WAT fat depots.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85152978602&doi=10.1007%2f978-1-0716-3167-6_12&partnerID=40&md5=7acadd909c2b526f8444e8b1982fd3d1
https://scholars.lib.ntu.edu.tw/handle/123456789/632574
ISBN: 978-1-0716-3166-9
978-1-0716-3167-6
ISSN: 10643745
DOI: 10.1007/978-1-0716-3167-6_12
SDG/Keyword: [SDGs]SDG3
Appears in Collections:動物科學技術學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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