|Title:||Copy number variation of gasdermin D gene is associated with atrial fibrillation-related thromboembolic stroke||Authors:||PANG-SHUO HUANG
Chuang, Eric Y
|Keywords:||Atrial fibrillation • Stroke • Genetic study • GSDMD • Asia||Issue Date:||19-May-2023||Publisher:||OXFORD UNIV PRESS||Journal Volume:||25||Journal Issue:||5||Start page/Pages:||euad103||Source:||Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology||Abstract:||
Atrial fibrillation (AF) is one of the major causes of ischaemic stroke. In addition to clinical risk evaluated by the CHA2DS2-VASC score, the impact of genetic factors on the risk of AF-related thromboembolic stroke has been largely unknown. We found several copy number variations (CNVs) in novel genes that were associated with thromboembolic stroke risk in our AF patients by genome-wide approach. Among them, the gasdermin D (GSDMD) gene was related to inflammation. We aimed to test whether GSDMD deletion was associated with AF-related stroke.
|Appears in Collections:||醫學系|
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