https://scholars.lib.ntu.edu.tw/handle/123456789/632612| Title: | Copy number variation of gasdermin D gene is associated with atrial fibrillation-related thromboembolic stroke | Authors: | PANG-SHUO HUANG JEN-FANG CHENG Li, Guan-Wei Chuang, Eric Y JIEN-JIUN CHEN Chiu, Fu-Chun CHO-KAI WU YI-CHIH WANG JUEY-JEN HWANG CHIA-TI TSAI |
Keywords: | Atrial fibrillation • Stroke • Genetic study • GSDMD • Asia | Issue Date: | 19-May-2023 | Publisher: | OXFORD UNIV PRESS | Journal Volume: | 25 | Journal Issue: | 5 | Start page/Pages: | euad103 | Source: | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology | Abstract: | Atrial fibrillation (AF) is one of the major causes of ischaemic stroke. In addition to clinical risk evaluated by the CHA2DS2-VASC score, the impact of genetic factors on the risk of AF-related thromboembolic stroke has been largely unknown. We found several copy number variations (CNVs) in novel genes that were associated with thromboembolic stroke risk in our AF patients by genome-wide approach. Among them, the gasdermin D (GSDMD) gene was related to inflammation. We aimed to test whether GSDMD deletion was associated with AF-related stroke. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/632612 | ISSN: | 1099-5129 | DOI: | 10.1093/europace/euad103 |
| Appears in Collections: | 醫學系 |
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