https://scholars.lib.ntu.edu.tw/handle/123456789/632621
標題: | An Electrochemical o-Phthalaldehyde Sensor Using a Modified Disposable Screen-Printed Electrode with Polyacrylate Hydrogel for Concentration Verification of Clinical Disinfectant | 作者: | RICHIE CHEN PO-CHUAN HSIEH Lin, Jia Sin TZONG-JIH CHENG |
關鍵字: | disinfectant; electrochemical sensor; hydrogel; o-phthalaldehyde (OPA); screen-printed carbon electrode (SPCE) | 公開日期: | 1-四月-2023 | 出版社: | MDPI | 卷: | 13 | 期: | 4 | 來源出版物: | Biosensors | 摘要: | The study proposes an o-phthalaldehyde (OPA) sensor for rapid and reliable detection of OPA in healthcare disinfection practices, based on a hydrogel-modified screen-printed carbon electrode strip. The hydrogel film, which contains glycine and N-acetylcysteine, reacts with OPA to produce a reductive isoindole derivative. The derivative is then oxidized for OPA determination using cyclic voltammetry. The proposed sensor achieves an optimal detection time of 20–30 s and requires only a small analyte volume of 5 µL. It exhibits good precision (10%) and sensitivity (3.3 μA/cm2 mM) in a phosphate-buffered solution (pH 7.6), with excellent linearity (R2 > 0.97) and precision (<3%) in the detection range (0.2–0.6%) required for clinical OPA solutions. Moreover, the sensor demonstrates good concentration verification of Cidex-OPA disinfection in healthcare institutes, with high sensitivity (18.28 μA/cm2 mM) and precision around the minimum effective concentration (0.3%). Overall, the proposed sensor offers a promising and practical solution for accurate and reliable OPA detection in clinical disinfection practices. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85153681653&doi=10.3390%2fbios13040485&partnerID=40&md5=67b735908c93746a76821a736fb13f2a https://scholars.lib.ntu.edu.tw/handle/123456789/632621 |
ISSN: | 2079-6374 | DOI: | 10.3390/bios13040485 |
顯示於: | 生物機電工程學系 |
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