Joint Asian Pacific Association of Gastroenterology (APAGE)-Asian Pacific Society of Digestive Endoscopy (APSDE) clinical practice guidelines on the use of non-invasive biomarkers for diagnosis of colorectal neoplasia
Journal
Gut
Journal Volume
72
Journal Issue
7
Pages
1240
Date Issued
2023-07
Author(s)
Chan, Francis K L
Wong, Martin C S
Chan, Andrew T
East, James E
Makharia, Govind K
Weller, David
Ooi, Choon Jin
Limsrivilai, Julajak
Saito, Yutaka
Hang, Dao V
Emery, Jon D
Makmun, Dadang
Wu, Kaichun
Ali, Raja Affendi Raja
Ng, Siew C
Abstract
Screening for colorectal cancer (CRC) is effective in reducing CRC related mortality. Current screening methods include endoscopy based and biomarker based approaches. This guideline is a joint official statement of the Asian Pacific Association of Gastroenterology (APAGE) and the Asian Pacific Society of Digestive Endoscopy (APSDE), developed in response to the increasing use of, and accumulating supportive evidence for the role of, non-invasive biomarkers for the diagnosis of CRC and its precursor lesions. A systematic review of 678 publications and a two stage Delphi consensus process involving 16 clinicians in various disciplines was undertaken to develop 32 evidence based and expert opinion based recommendations for the use of faecal immunochemical tests, faecal based tumour biomarkers or microbial biomarkers, and blood based tumour biomarkers for the detection of CRC and adenoma. Comprehensive up-to-date guidance is provided on indications, patient selection and strengths and limitations of each screening tool. Future research to inform clinical applications are discussed alongside objective measurement of research priorities. This joint APAGE-APSDE practice guideline is intended to provide an up-to-date guide to assist clinicians worldwide in utilising non-invasive biomarkers for CRC screening; it has particular salience for clinicians in the Asia-Pacific region.
Subjects
clinical decision making; colorectal cancer; screening; tumour markers
SDGs
Publisher
BMJ PUBLISHING GROUP
Type
journal article