https://scholars.lib.ntu.edu.tw/handle/123456789/632709
標題: | Strategy of blood pressure intervention in the elderly hypertensive patients (STEP): Rational, design, and baseline characteristics for the main trial | 作者: | Zhang, Shuyuan Wu, Shouling Ren, Jie Chen, Xiaoping Zhang, Xinjun Feng, Yingqing Zhou, Xiaoyang Zhu, Bingpo Yang, Jinfeng Tian, Gang Jiang, Yinong Guo, Zihong Li, Yuming TZUNG-DAU WANG Kario, Kazuomi Zhang, Weili Cai, Jun |
關鍵字: | Essential hypertension; Major adverse cardiovascular events; Mobile applications; Randomized clinical trial; Systolic blood pressure | 公開日期: | 二月-2020 | 出版社: | ELSEVIER SCIENCE INC | 卷: | 89 | 起(迄)頁: | 105913 | 來源出版物: | Contemporary clinical trials | 摘要: | The optimal systolic blood pressure (SBP) treatment target in elderly people is full of challenge, and non-adherence is one major cause of uncontrolled BP. The Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial is a multi-center, randomized controlled trial that aims to examine whether an intensive treatment (110 ≤ SBP < 130 mmHg) will provide more benefits in lowering cardiovascular events than a mild treatment (130 ≤ SBP < 150 mmHg) among people aged 60-80 years. From January 10, 2017 to December 31, 2017, 8511 patients with primary hypertension were recruited at 42 clinical centers throughout China and randomly assigned to the intensive or standard treatment in 1:1 ratio, in which clinical sites are considered as a stratification factor in randomization. Participants will be followed for an average of four years. All participants used the same validated home BP device and all centers used the same validated office BP device which can automatically upload the readings to a data center. The hospitals were randomly classified as the smartphone-based App center or usual care center in 1:1 ratio for the secondary purpose to study the effect of App management on BP control. In this trial, mean age of participants was 66.2 ± 4.8 years, 24.1% were in the range of 70-80 years, and 65% were at high-risk with the 10-year Framingham risk score ≥ 15%. In conclusion, STEP will provide evidence not only to address appropriate target of BP control among hypertensive patients aged 60-80 years, but also to assess an effective model of App management for hypertension. Trial Registration number: ClinicalTrials. gov. Unique identifier: NCT03015311. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/632709 | ISSN: | 1551-7144 | DOI: | 10.1016/j.cct.2019.105913 |
顯示於: | 醫學系 |
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