https://scholars.lib.ntu.edu.tw/handle/123456789/632859
標題: | Poloxamer-Modified Poly (Vinylidene Fluoride) (Pvdf) Biomaterials for Removal of Microvesicles and Cytokines from Plasma | 作者: | Lo, Shyh-Chyi Lin, Kuan-Hung Wang, Yu-Chieh CHIH-HAO CHANG Young, Tai-Horng |
關鍵字: | cytokines;microvesicles (MVs);poloxamer;poly (vinylidene fluoride) (PVDF);polyvinylpyrrolidone (PVP);two-step membrane formation | 公開日期: | 1-八月-2022 | 來源出版物: | SSRN | 摘要: | For extracorporeal blood purification to modulate the inflammatory response of patients with sepsis, biomaterials designed in the membrane form should provide better filtration performance for the removal of inflammatory mediators such as microvesicles (MVs) and cytokines, and better antifouling abilities and hemocompatibility. To meet such specific application, there is a need to prepare biomaterials with appropriate pore size while maintaining appropriate surface property simultaneously. This study prepared poly (vinylidene fluoride) (PVDF) biomaterials by a two-step process, controlling PVDF physical structure using polyvinylpyrrolidone (PVP) as the pore former in the first step followed by immersing PVDF in the poloxamer solution to modify the hydrophobic surface property. In the second step, hydrophobic propylene glycol segments and hydrophilic ethylene glycol segments of poloxamer play the anchoring role onto the hydrophobic PVDF surface and the wetting role in enhancing PVDF surface hydrophilicity, respectively. The results indicate that the simple post treatment without complicated chemical reactions not only decreased the plasma protein adsorption, but also improved the plasma clotting time of PVDF. More importantly, poloxamer-modified PVDF did not lose performance for removing MVs and cytokines, even exhibited more effective results than unmodified PVDF. Therefore, our strategy shows plasma flux, filtration, plasma protein adsorption, and plasma clotting time of PVDF could be optimized by using PVP and poloxamer separately in two different processes, which have the potential for future applications in the extracorporeal blood purification. © 2022, The Authors. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/632859 | ISSN: | 15565068 |
顯示於: | 醫學系 |
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