https://scholars.lib.ntu.edu.tw/handle/123456789/633041
標題: | Vitreoretinal Interface Changes After Anti-vascular Endothelial Growth Factor Treatment in Highly Myopic Eyes: A Real-World Study | 作者: | Tsui, Mei Chi YI-TING HSIEH TSO-TING LAI Hsia, Yun Wang, Shih Wen Ma, I. Hsin Hung, Kuo Chi CHANG-PING LIN CHANG-HAO YANG CHUNG-MAY YANG TZYY-CHANG HO |
關鍵字: | Anti-vascular endothelial growth factor | High myopia | Myopic choroidal neovascularization | Myopic macular retinoschisis | Myopic traction maculopathy | Vitreoretinal interface | 公開日期: | 1-六月-2023 | 出版社: | SPRINGER INT PUBL AG | 卷: | 12 | 期: | 3 | 來源出版物: | Ophthalmology and Therapy | 摘要: | Introduction: To investigate changes in the vitreoretinal interface after anti-vascular endothelial growth factor (anti-VEGF) treatment in highly myopic eyes. Methods: Eyes with myopic choroidal neovascularization (mCNV) treated with intravitreal injection of anti-VEGF in a single-center were retrospectively reviewed. Fundus abnormalities and features of optical computed tomography were studied. Results: A total of 295 eyes from 254 patients were recruited to the study. Prevalence of myopic macular retinoschisis (MRS) was 25.4%, and the rates of progression and onset of MRS were 75.9% and 16.2%, respectively. Outer retinal schisis (β = 8.586, p = 0.003) and lamellar macular hole (LMH) (β = 5.015, p = 0.043) at baseline were identified risk factors for progression and onset of MRS, whereas male sex (β = 9.000, p = 0.039) and outer retinal schisis at baseline (β = 5.250, p = 0.010) were risk factors for MRS progression. Progression of MRS was first detected in outer retinal layers in 48.3% of eyes. Thirteen eyes required surgical intervention. Spontaneous improvements of MRS were observed in five eyes (6.3%). Conclusion: Changes in the vitreoretinal interface, such as progression, onset, and improvement of MRS, were observed after anti-VEGF treatment. Outer retinal schisis and LMH were risk factors of progression and onset of MRS after anti-VEGF treatment. Intravitreal injection of ranibizumab and retinal hemorrhage were protective factors for surgical intervention for vision-threatening MRS. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633041 | ISSN: | 21938245 | DOI: | 10.1007/s40123-023-00701-4 |
顯示於: | 醫學系 |
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