https://scholars.lib.ntu.edu.tw/handle/123456789/633294
標題: | 14-3-3 proteins regulate cullin 7-mediated Eag1 degradation | 作者: | Hsieh, Chang-Heng Chou, Chia-Cheng Fang, Ya-Ching Hsu, Po-Hao Chiu, Yi-Hung Yang, Chi-Sheng Jow, Guey-Mei CHIH-YUNG TANG Jeng, Chung-Jiuan |
關鍵字: | Lysosomal degradation; Potassium channel; Proteasomal degradation; Protein interaction; Protein stability; Ubiquitin ligase | 公開日期: | 30-一月-2023 | 卷: | 13 | 期: | 1 | 來源出版物: | Cell & bioscience | 摘要: | Mutations in the human gene encoding the neuron-specific Eag1 (KV10.1; KCNH1) potassium channel are linked to congenital neurodevelopmental diseases. Disease-causing mutant Eag1 channels manifest aberrant gating function and defective protein homeostasis. Both the E3 ubiquitin ligase cullin 7 (Cul7) and the small acid protein 14-3-3 serve as binding partners of Eag1. Cul7 mediates proteasomal and lysosomal degradation of Eag1 protein, whereas over-expression of 14-3-3 notably reduces Eag1 channel activity. It remains unclear whether 14-3-3 may also contribute to Eag1 protein homeostasis. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633294 | ISSN: | 2045-3701 | DOI: | 10.1186/s13578-023-00969-w |
顯示於: | 生理學科所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。