https://scholars.lib.ntu.edu.tw/handle/123456789/633306
標題: | Achromatic and chromatic contrast discrimination in patients with type 2 diabetes | 作者: | LI-TING TSAI Chen, Chien-Chung Hou, Chiun-Ho Liao, Kuo-Meng |
公開日期: | 8-五月-2023 | 卷: | 13 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | Effects of type 2 diabetes on achromatic and chromatic contrast sensitivity (CS) are still controversial. In this study, we aimed to investigate CS in patients without diabetic retinopathy (no-DR) and in those with non-proliferative DR (NPDR) and proliferative DR (PDR) using psychophysical methods with transient and sustained achromatic stimuli and color patches. Achromatic CS was measured with the pulsed pedestal (PP) paradigm (7, 12, and 19 cd/m2) and pedestal-△-pedestal (P-△-P) paradigm (11.4, 18, and 28.5 cd/m2). A chromatic discrimination paradigm that assesses protan, deutan, and tritan color vision was adopted. Forty-two patients (no-DR n = 24, NPDR n = 12, PDR = 6; male n = 22, mean age = 58.1 y/o) and 38 controls (male n = 18, mean age = 53.4 y/o) participated. In patients, mean thresholds were higher than in controls and linear trends were significant in most conditions. For the PP paradigm, differences were significant in the PDR and NPDR groups in the 7 and 12 cd/m2 condition. For the P-△-P paradigm, differences were only significant in the PDR group in the 11 cd/m2 condition. Chromatic contrast loss was significant in the PDR group along the protan, deutan and tritan axes. The results suggest independent involvements of achromatic and chromatic CS in diabetic patients. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633306 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-023-34407-1 |
顯示於: | 職能治療學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。