https://scholars.lib.ntu.edu.tw/handle/123456789/633339
標題: | Successful Repigmentation of Full-Thickness Wound Healing in Fraser’s Dolphins (Lagenodelphis hosei) | 作者: | Su, Chen Yi Wang, Hao Ven Hughes, Michael W. Liu, Tzu-Yu Chuong, Cheng Ming WEI-CHENG YANG |
關鍵字: | dolphins; full-thickness wound; melanin; melanocytes; repigmentation | 公開日期: | 1-六月-2022 | 卷: | 12 | 期: | 12 | 來源出版物: | Animals | 摘要: | Fraser’s dolphins (Lagenodelphis hosei) exhibit the capability to restore nearly normal pigmentation after full-thickness wounding. However, the association among melanocytes, melanin and skin pigmentation during wound healing in cetaceans has yet to be addressed. Here, the number of melanocytes and the distribution of melanocytes and melanin in different-colored skin and different wound-healing stages in Fraser’s dolphins were analyzed by using Fontana–Masson staining, immunofluorescence staining and immunohistochemical staining. It was noticed that there was the highest number of melanocytes in dark skin and the lowest number of melanocytes in white skin. The appearance of functional melanocytes and full-melanized neoepidermis was observed in the early stage of wound healing in Fraser’s dolphins. Furthermore, the melanocyte number and skin pigmentation and pattern in healed wounds recovered to a similar condition of unwounded skin. This study provides fundamental knowledge of skin repigmentation in cetaceans for further research, and it will be warranted to elucidate the mechanisms of the replenishment of melanocytes and the regulation of melanocyte activity that contribute to the successful repigmentation in cetacean skin wounds. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85131595832&doi=10.3390%2fani12121482&partnerID=40&md5=33a0c78c280be234a823eacc0e1ed620 https://scholars.lib.ntu.edu.tw/handle/123456789/633339 |
ISSN: | 2076-2615 | DOI: | 10.3390/ani12121482 |
顯示於: | 獸醫學系 |
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