https://scholars.lib.ntu.edu.tw/handle/123456789/633478
標題: | Effects of selective cyclooxygenase-2 inhibitor robenacoxib on primary cells derived from feline injection-site sarcoma | 作者: | Lu, Chen Hui SHU-HAN YU CHING-HO WU Yeh, Jason Lih Seng HUI-WEN CHANG CHIAN-REN JENG YEN-CHEN CHANG |
關鍵字: | cyclooxygenase-2 | feline injection-site sarcoma | primary cells | robenacoxib | 公開日期: | 1-一月-2023 | 來源出版物: | Journal of Cellular and Molecular Medicine | 摘要: | Feline injection-site sarcomas (FISSs) are highly invasive malignant mesenchymal neoplasms that arise from injection sites in cats. Although the tumorigenesis of FISSs is still uncertain, there is a consensus that FISS is associated with chronic inflammation caused by irritation of injection-related trauma and foreign chemical substances. Chronic inflammation can provide a proper microenvironment for tumour development, which has been known as one of the risk factors of tumorigenesis in many tumours. To investigate the tumorigenesis of FISS and screen for its potential therapeutic targets, cyclooxygenase-2 (COX-2), an inflammation-enhancing enzyme, was selected as a target for this study. In vitro experiments using FISS- and normal tissue-derived primary cells and robenacoxib, a highly selective COX-2 inhibitor, were performed. The results demonstrated that expression of COX-2 could be detected in formalin-fixed and paraffin-embedded FISS tissues and FISS-derived primary cells. Cell viability, migration and colony formation of FISS-derived primary cells were inhibited, and cell apoptosis was enhanced by robenacoxib in a dose-dependent manner. However, susceptibility to robenacoxib varied in different lines of FISS primary cells and was not completely correlated with COX-2 expression. Our results suggest that COX-2 inhibitors could be potential adjuvant therapeutics against FISSs. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85162108405&doi=10.1111%2fjcmm.17717&partnerID=40&md5=5c4236969a924406f8ceb7160ec25111 https://scholars.lib.ntu.edu.tw/handle/123456789/633478 |
ISSN: | 15821838 | DOI: | 10.1111/jcmm.17717 |
顯示於: | 農藝學系 |
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