https://scholars.lib.ntu.edu.tw/handle/123456789/633504
標題: | Hepatitis C virus genotype 1b increases cumulative lifetime risk of hepatocellular carcinoma | 作者: | Lee, Mei-Hsuan Yang, Hwai-I Lu, Sheng-Nan Jen, Chin-Lan You, San-Lin Wang, Li-Yu L'Italien, Gilbert Chen, Chien-Jen Yuan, Yong REVEAL-HCV Study Group (CHYI-FENG JAN) |
關鍵字: | HCV RNA levels; HCV variability; long-term liver progression | 公開日期: | 1-九月-2014 | 卷: | 135 | 期: | 5 | 來源出版物: | International journal of cancer | 摘要: | The association between subtypes of hepatitis C virus (HCV) and risk of hepatocellular carcinoma (HCC) remained inconclusive and evaluated in both case-control and cohort studies. In the case-control study, 397 HCC cases from medical centers were compared with 410 community-based non-HCC controls. All of them were anti-HCV-seropositive, HBsAg-seronegative with serum HCV RNA levels ≥1,000 IU/mL. Logistic regression models were used to estimate the odds ratio (OR) with 95% confidence interval (95% CI) of HCV subtype after controlling for other HCC risk factors. In the cohort study, 866 anti-HCV-seropositive individuals were followed from 1991 to 2008 to assess the long-term HCC predictability of HCV subtypes. Newly developed HCC cases were ascertained by follow-up health examinations and computerized linkage with national databases. The percentage of HCV 1b subtype was higher among HCC cases than controls (64 vs. 55%, p < 0.001). Participant infected with HCV 1b had a higher mean serum HCV RNA level (2.0 × 10(6) IU/mL) than those infected with HCV non-1b (1.2 × 10(6) IU/mL, p < 0.001). The multivariate-adjusted OR (95% CI) of developing HCC for HCV 1b comparing to non-1b was 1.43 (1.02-2.02). After the long-term follow-up, the cumulative lifetime (30-80 years old) HCC risk was 19.2 and 29.7% for patients infected with HCV non-1b and 1b, respectively (p < 0.001). The multivariate-adjusted hazard ratio (95% CI) was 1.85 (1.06-3.22) for HCV 1b compared to non-1b. HCV subtype 1b, the most prevalent subtype in Taiwan, was associated with an increased HCC risk and a proactive clinical management is suggested for patients with HCV 1b. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633504 | ISSN: | 00207136 | DOI: | 10.1002/ijc.28753 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。