https://scholars.lib.ntu.edu.tw/handle/123456789/633547
標題: | Prognostic Validity of the American Joint Committee on Cancer Eighth Edition Staging System for Well-Differentiated Pancreatic Neuroendocrine Tumors A Retrospective Multinational Multicenter Study | 作者: | Wang, Hebin Ding, Ding Qin, Tingting Liu, Jun Zhang, Hang Zhao, Junfang Wu, Chien-Hui Javed, Ammar Wolfgang, Christopher Guo, Shiwei Chen, Qinmin Zhao, Weihong Shi, Wei Zhu, Feng Guo, Xingjun Li, Xu Peng, Feng He, Ruizhi Xu, Simiao Jin, Jikuan Wu, Yi Nuer, Abula Edil, Barish YU-WEN TIEN et al., |
關鍵字: | Pancreatic neuroendocrine tumors;Prognosis;Staging;Survival | 公開日期: | 8-十月-2020 | 來源出版物: | ResearchSquare | 摘要: | Background: There is no widely-accepted staging system for pancreatic neuroendocrine tumors (pNETs). The aim of this study was to validate the American Joint Committee on Cancer (AJCC) 8th edition staging system for well-differentiated (G1/G2) pNETs. Methods: A multicenter dataset (n=1086) was used to evaluate the application of the AJCC 7th and 8th, the European Neuroendocrine Tumor Society (ENETS), and the modified ENETS (mENETS) staging systems for well-differentiated pNETs. Results: The proportion of patients with stage III tumors was extremely low (1.1%) according to the AJCC 7th staging system. For the ENETS staging system, patients with stage IIIA disease had worse estimated mean survival than patients with stage IIIB disease (78.9 vs. 107.3 months). When comparing with patients in stage I, the AJCC 7th, ENETS, and mENETS staging systems showed good performance in discriminating between stages; however, there was no significant difference in some stages when the reference was defined as the earlier stage. When the reference was defined as stage I or the earlier stage, there was a significant inter-stage difference in the AJCC 8th staging system. Conclusions: The AJCC 8th staging system is more suitable for pNETs than other TNM staging systems and may be adopted in clinical practice. © 2020, CC BY. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633547 | DOI: | 10.21203/rs.3.rs-86061/v1 |
顯示於: | 醫學系 |
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