https://scholars.lib.ntu.edu.tw/handle/123456789/633570
標題: | Correlation of Body Mass Index with Oncologic Outcomes in Colorectal Cancer Patients: A Large Population-Based Study | 作者: | Chiu, Chong-Chi Ho, Chung-Han Hung, Chao-Ming Chao, Chien-Ming Lai, Chih-Cheng Chen, Chin-Ming Liao, Kuang-Ming Wang, Jhi-Joung Wu, Yu-Cih Shi, Hon-Yi PO-HUANG LEE Lee, Hui-Ming Yeh, Li-Ren Soong, Tien-Chou Chiang, Shyh-Ren Cheng, Kuo-Chen |
關鍵字: | body mass index; colorectal cancer; colorectal cancer-specific survival; disease-free survival; oncologic prognosis; overall survival | 公開日期: | 17-七月-2021 | 卷: | 13 | 期: | 14 | 來源出版物: | Cancers | 摘要: | It has been acknowledged that excess body weight increases the risk of colorectal cancer (CRC); however, there is little evidence on the impact of body mass index (BMI) on CRC patients' long-term oncologic results in Asian populations. We studied the influence of BMI on overall survival (OS), disease-free survival (DFS), and CRC-specific survival rates in CRC patients from the administrative claims datasets of Taiwan using the Kaplan-Meier survival curves and the log-rank test to estimate the statistical differences among BMI groups. Underweight patients (<18.50 kg/m2) presented higher mortality (56.40%) and recurrence (5.34%) rates. Besides this, they had worse OS (aHR:1.61; 95% CI: 1.53-1.70; p-value: < 0.0001) and CRC-specific survival (aHR:1.52; 95% CI: 1.43-1.62; p-value: < 0.0001) rates compared with those of normal weight patients (18.50-24.99 kg/m2). On the contrary, CRC patients belonging to the overweight (25.00-29.99 kg/m2), class I obesity (30.00-34.99 kg/m2), and class II obesity (≥35.00 kg/m2) categories had better OS, DFS, and CRC-specific survival rates in the analysis than the patients in the normal weight category. Overweight patients consistently had the lowest mortality rate after a CRC diagnosis. The associations with being underweight may reflect a reverse causation. CRC patients should maintain a long-term healthy body weight. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633570 | ISSN: | 2072-6694 | DOI: | 10.3390/cancers13143592 |
顯示於: | 醫學系 |
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