https://scholars.lib.ntu.edu.tw/handle/123456789/633600
標題: | Different immune contextures underlie tumor site-specific responses to immune checkpoint blockade in esophageal cancer | 作者: | JHE-CYUAN GUO Hsu, Chia-Lang MIN-SHU HSIEH CHIA-CHI LIN TA-CHEN HUANG HUNG-YANG KUO YU-YUN SHAO CHIH-HUNG HSU |
關鍵字: | differential response; esophageal squamous cell carcinoma; immune checkpoint inhibitor; immune contexture; tumor site specific | 公開日期: | 20-六月-2023 | 來源出版物: | Thoracic cancer | 摘要: | Immune checkpoint inhibitors (ICIs) have demonstrated efficacy in advanced esophageal squamous cell carcinoma (ESCC). Heterogeneous responses to ICIs have been reported previously. Here, we describe a patient with advanced ESCC exhibiting a response to durvalumab plus tremelimumab for more than 6 months except primary resistant esophageal tumor. The esophageal tumor had higher regulatory T cells, neutrophils, and mast cells scores estimated by NanoString platform than hepatic tumor. The immunohistochemistry study confirmed higher expression levels of Foxp3, and myeloperoxidase (MPO) in the esophageal tumor. The different immune contextures may underlie the heterogeneous responses to ICI combination in this ESCC patient. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/633600 | ISSN: | 17597706 | DOI: | 10.1111/1759-7714.14997 |
顯示於: | 腫瘤醫學研究所 |
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