https://scholars.lib.ntu.edu.tw/handle/123456789/634296
標題: | A prolonged stress rat model recapitulates some PTSD-like changes in sleep and neuronal connectivity | 作者: | Lo, Yun Yi, Pei Lu YI-TSE HSIAO Lee, Tung Yen FANG-CHIA CHANG |
公開日期: | 1-十二月-2023 | 卷: | 6 | 期: | 1 | 來源出版物: | Communications Biology | 摘要: | Chronic post-traumatic stress disorder (PTSD) exhibits psychological abnormalities during fear memory processing in rodent models. To simulate long-term impaired fear extinction in PTSD patients, we constructed a seven-day model with multiple prolonged stress (MPS) by modifying manipulation repetitions, intensity, and unpredictability of stressors. Behavioral and neural changes following MPS conveyed longitudinal PTSD-like effects in rats for 6 weeks. Extended fear memory was estimated through fear retrieval induced-freezing behavior and increased long-term serum corticosterone concentrations after MPS manipulation. Additionally, memory retrieval and behavioral anxiety tasks continued enhancing theta oscillation activity in the prefrontal cortex-basal lateral amygdala-ventral hippocampus pathway for an extended period. Moreover, MPS and remote fear retrieval stimuli disrupted sleep-wake activities to consolidate fear memory. Our prolonged fear memory, neuronal connectivity, anxiety, and sleep alteration results demonstrated integrated chronic PTSD symptoms in an MPS-induced rodent model. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164541867&doi=10.1038%2fs42003-023-05090-9&partnerID=40&md5=4e0153275471727bb33651eef0d4cd11 https://scholars.lib.ntu.edu.tw/handle/123456789/634296 |
ISSN: | 2399-3642 | DOI: | 10.1038/s42003-023-05090-9 |
顯示於: | 獸醫學系 |
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