https://scholars.lib.ntu.edu.tw/handle/123456789/634499
標題: | The significance of dense fine speckled pattern in antinuclear antibody-associated rheumatic disease and coexisting autoantibodies: A propensity score-matched cohort study | 作者: | CHIAO-FENG CHENG Lan, Ting Yuan JUI-HUNG KAO CHENG-HSUN LU Chang, Yu Cheng YI-MIN HUANG FENG-JUNG YANG Chen, Jen Hao YEN-CHUN LIN Chuang, Chieh An Chang, Chih Hui KO-JEN LI CHIEH-YU SHEN SONG-CHOU HSIEH |
關鍵字: | ANA-associated rheumatic disease | anti-DFS70 antibody | anti-nuclear antibody | dense fine speckled | diagnosis | 公開日期: | 1-一月-2023 | 來源出版物: | International Journal of Rheumatic Diseases | 摘要: | Aim: To investigate the relationship between the prevalence of antinuclear antibody (ANA) -associated rheumatic diseases (AARD) and the presence of dense fine speckled (DFS) and homogeneous patterns in ANA tests. Methods: This retrospective study enrolled adult patients with either a DFS or homogeneous pattern in their ANA test. A mixed pattern was defined as the presence of more than one pattern reported in the test. The presence of anti-DFS70 antibodies and other common autoantibodies were detected using EUROLINE ANA Profile 23. A 1:2 propensity score matching was applied to control for demographic and other interfering factors. Results: A total of 59 patients with a DFS pattern were enrolled and compared with a matched homogeneous group. The DFS group had a significantly lower prevalence of AARD (3.4% vs. 16.9%, p =.008) and the subgroup with anti-DFS70 antibodies showed an even lower prevalence (2% vs. 20%, p =.002). Among the 33 patients with monospecific anti-DFS70 antibodies, five had a mixed pattern, and all patients with common autoantibodies had an isolated DFS pattern. Conclusions: The findings of this study suggest that patients with a DFS pattern in their ANA test may have a lower prevalence of AARD compared with those with a homogeneous pattern. However, an isolated DFS pattern in ANA testing does not necessarily indicate the presence of monospecific anti-DFS70 antibodies or AARD. Confirmatory testing for the monospecific anti-DFS70 antibody is mandatory to exclude AARD. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/634499 | ISSN: | 17561841 | DOI: | 10.1111/1756-185X.14789 |
顯示於: | 醫學院附設癌醫中心醫院(臺大癌醫) |
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