Alleviation of PM2.5-induced alveolar macrophage inflammation using extract of fermented Chenopodium formosanum Koidz sprouts via regulation of NF-κB pathway
Journal
Journal of ethnopharmacology
Journal Volume
318
Journal Issue
Pt B
Date Issued
2023-08-02
Author(s)
Hsieh, Chen-Che
Kuo, Hsing-Chun
Cheng, Kai-Wen
Hsu, Cheng-Chih
Lin, Yi-Pin
Khumsupan, Darin
Lin, Shin-Ping
Angkawijaya, Artik Elisa
Abstract
Particulate matter 2.5 (PM2.5) is a dangerous airborne pollutant that has become a global issue due to its detrimental effect on macrophages. Chenopodium formosanum Koidz (Djulis), a native plant from Taiwan well known for its high antioxidant content and is frequently used in ethnomedicine, shows promise as a novel phytomedicine to combat against oxidative stress caused by PM2.5. However, the protective mechanism of Djulis against PM2.5 still remains unclear.
Subjects
Alveolar macrophage; Anti-inflammatory; Chenopodium formosanum Koidz; Molecular docking; NF-κB pathway; Particulate matter
Type
journal article