https://scholars.lib.ntu.edu.tw/handle/123456789/634608
標題: | Light disrupts social memory via a retina-to-supraoptic nucleus circuit | 作者: | Huang, Yu-Fan Liao, Po-Yu Yu, Jo-Hsien SHIH-KUO CHEN |
關鍵字: | Intrinsically photosensitive retinal ganglion cells; melanopsin; oxytocin; social recognition memory; supraoptic nucleus | 公開日期: | 2-八月-2023 | 出版社: | John Wiley and Sons Inc | 卷: | 2023 | 期: | e56839 | 來源出版物: | EMBO reports | 摘要: | The formation of social memory between individuals of the opposite sex is crucial for expanding mating options or establishing monogamous pair bonding. A specialized neuronal circuit that regulates social memory could enhance an individual's mating opportunities and provide a parallel pathway for computing social behaviors. While the influence of light exposure on various forms of memory, such as fear and object memory, has been studied, its modulation of social recognition memory remains unclear. Here, we demonstrate that acute exposure to light impairs social recognition memory (SRM) in mice. Unlike sound and touch stimuli, light inhibits oxytocin neurons in the supraoptic nucleus (SON) via M1 SON-projecting intrinsically photosensitive retinal ganglion cells (ipRGCs) and GABAergic neurons in the perinuclear zone of the SON (pSON). We further show that optogenetic activation of SON oxytocin neurons using channelrhodopsin is sufficient to enhance SRM performance, even under light conditions. Our findings unveil a dedicated neuronal circuit through which luminance affects SRM, utilizing a non-image-forming visual pathway, distinct from the canonical modulatory role of the oxytocin system. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/634608 | ISSN: | 1469221X | DOI: | 10.15252/embr.202356839 |
顯示於: | 生命科學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。