https://scholars.lib.ntu.edu.tw/handle/123456789/634664
標題: | The versatile roles of lumican in eye diseases: A review | 作者: | Tsui, Mei Chi Liu, Hsin Yu HSIAO-SANG CHU WEI-LI CHEN FUNG-RONG HU Kao, Winston W.Y. I-JONG WANG |
關鍵字: | Corneal inflammation | Corneal transparency | Corneal wound healing | Lumican | Myopia | Scleral integrity | Small leucine-rich proteoglycans (SLRP) | 公開日期: | 1-七月-2023 | 卷: | 29 | 來源出版物: | Ocular Surface | 摘要: | Lumican is a keratan sulfate proteoglycan that belongs to the small leucine-rich proteoglycan family. Research has lifted the veil on the versatile roles of lumican in the pathogenesis of eye diseases. Lumican has pivotal roles in the maintenance of physiological tissue homogenesis and is often upregulated in pathological conditions, e.g., fibrosis, scar tissue formation in injured tissues, persistent inflammatory responses and immune anomaly, etc. Herein, we will review literature regarding the role of lumican in pathogenesis of inherited congenital and acquired eye diseases, e.g., cornea dystrophy, cataract, glaucoma and chorioretinal diseases, etc. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/634664 | ISSN: | 15420124 | DOI: | 10.1016/j.jtos.2023.06.012 |
顯示於: | 醫學系 |
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