The versatile roles of lumican in eye diseases: A review
Journal
Ocular Surface
Journal Volume
29
Date Issued
2023-07-01
Author(s)
Abstract
Lumican is a keratan sulfate proteoglycan that belongs to the small leucine-rich proteoglycan family. Research has lifted the veil on the versatile roles of lumican in the pathogenesis of eye diseases. Lumican has pivotal roles in the maintenance of physiological tissue homogenesis and is often upregulated in pathological conditions, e.g., fibrosis, scar tissue formation in injured tissues, persistent inflammatory responses and immune anomaly, etc. Herein, we will review literature regarding the role of lumican in pathogenesis of inherited congenital and acquired eye diseases, e.g., cornea dystrophy, cataract, glaucoma and chorioretinal diseases, etc.
Subjects
Corneal inflammation | Corneal transparency | Corneal wound healing | Lumican | Myopia | Scleral integrity | Small leucine-rich proteoglycans (SLRP)
SDGs
Type
journal article