https://scholars.lib.ntu.edu.tw/handle/123456789/634683
標題: | Effects of task prioritization on a postural-motor task in early-stage Parkinson's disease: EEG connectivity and clinical implication | 作者: | CHENG-YA HUANG Chen, Liang-Chi RUEY-MEEI WU Hwang, Ing-Shiou |
關鍵字: | Dual-task; EEG; Functional connectivity; Parkinson’s disease; Task prioritization | 公開日期: | 八月-2022 | 卷: | 44 | 期: | 4 | 起(迄)頁: | 2061 | 來源出版物: | GeroScience | 摘要: | Appropriate attentional resource allocation could minimize exaggerated dual-task interference due to basal ganglia dysfunction in Parkinson's disease (PD). Here, we assessed the electroencephalography (EEG) functional connectivity to investigate how task prioritization affected posture-motor dual-tasks in PD. Sixteen early-stage PD patients and 16 healthy controls maintained balance in narrow stance alone (single-posture task) or while separating two interlocking rings (postural dual-task). The participants applied a posture-focus or supraposture-focus strategy in the postural dual-task. Postural sway dynamics, ring-touching time, and scalp EEG were analyzed. Both groups exhibited smaller postural sway size, postural determinism, and ring-touching time with the supraposture-focus versus posture-focus strategy. PD patients exhibited higher mean inter-regional connectivity strength than control subjects in both single and dual-task postural conditions. To cope with dual-task interference, PD patients increased inter-regional connectivity (especially with the posture-focus strategy), while control subjects reduced inter-regional connectivity. The difference in mean connectivity strength between the dual-task condition with supraposture-focus and single-posture condition was negatively correlated to the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part III total scores and hand-related sub-scores. Our findings suggest differential task prioritization effects on dual-task performance and cortical reorganization between early-stage PD and healthy individuals. Early-stage PD patients are advocated to use a supraposture-focus strategy during a postural dual-task. In addition, with a supraposture-focus strategy, PD patients with mild motor severity could increase compensatory inter-regional connectivity to cope with dual-task interference. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/634683 | ISSN: | 25092715 | DOI: | 10.1007/s11357-022-00516-4 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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