https://scholars.lib.ntu.edu.tw/handle/123456789/634748
標題: | Music Box-Inspired Semi-Automatic Hematocrit Validation Device | 作者: | Liao, You Mao Chiu, Ping Yeh Chien, Yuh Shiuan CHIEN-FU CHEN |
關鍵字: | Boycott effect | constant torque mechanism | hematocrit | point-of-care test | portable centrifuge | 公開日期: | 1-一月-2023 | 卷: | 8 | 期: | 8 | 來源出版物: | ACS Sensors | 摘要: | A high hematocrit (HCT) level is strongly associated with the risk of cardiovascular disease. For early diagnosis of cardiovascular disease, it is vital to regularly measure the HCT, which is typically achieved by centrifuging a blood sample to measure the percentage of red blood cells. However, the centrifugal modalities are usually bulky, expensive, and require a stable electric input, which restrict the availability. This research develops a semi-automatic and portable centrifugal device for HCT measurement. This torque-actuated semi-automatic centrifuge, which we call the tFuge, is inspired by a music box, allowing different operators to generate the same rhythm. It is electricity-free and can be controlled based on a constant torque mechanism. Repeatable test results can be received from among different users regardless of their age, sex, and activity. With the assistance of the Boycott effect on the tFuge, we proved that the HCT level is in high linearity to the length of the sedimentation of the blood cells in a tube (R2 = 0.99, sample HCT range 10-60%). The tFuge takes less than 4 min and requires no more than 10 μL of blood that can be obtained by a less-invasive finger prick to complete the testing procedure. Calibrated gradient numbers are printed onto the rotation disc for instant HCT results that can be read by the naked eye. We expect this proposed point-of-care testing device possesses the potential to replace the microhematocrit centrifuge in the regions with limited resources. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/634748 | ISSN: | 2379-3694 | DOI: | 10.1021/acssensors.3c00129 |
顯示於: | 應用力學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。