https://scholars.lib.ntu.edu.tw/handle/123456789/634826
標題: | The Antitumor Effect of Caffeic Acid Phenethyl Ester by Downregulating Mucosa-Associated Lymphoid Tissue 1 via AR/p53/NF-κB Signaling in Prostate Carcinoma Cells | 作者: | Chang, Kang-Shuo Tsui, Ke-Hung Hsu, Shu-Yuan Sung, Hsin-Ching Lin, Yu-Hsiang Hou, Chen-Pang PEI-SHAN YANG Chen, Chien-Lun Feng, Tsui-Hsia Juang, Horng-Heng |
關鍵字: | AR; BTG2; CAPE; MALT1; NDRG1; NF-κB; p53; prostate cancer | 公開日期: | 6-一月-2022 | 卷: | 14 | 期: | 2 | 來源出版物: | Cancers | 摘要: | Caffeic acid phenethyl ester (CAPE), a honeybee propolis-derived bioactive ingredient, has not been extensively elucidated regarding its effect on prostate cancer and associated mechanisms. The mucosa-associated lymphoid tissue 1 gene (MALT1) modulates NF-κB signal transduction in lymphoma and non-lymphoma cells. We investigated the functions and regulatory mechanisms of CAPE in relation to MALT1 in prostate carcinoma cells. In p53- and androgen receptor (AR)-positive prostate carcinoma cells, CAPE downregulated AR and MALT1 expression but enhanced that of p53, thus decreasing androgen-induced activation of MALT1 and prostate-specific antigen expressions. p53 downregulated the expression of MALT in prostate carcinoma cells through the putative consensus and nonconsensus p53 response elements. CAPE downregulated MALT1 expression and thus inhibited NF-κB activity in p53- and AR-negative prostate carcinoma PC-3 cells, eventually reducing cell proliferation, invasion, and tumor growth in vitro and in vivo. CAPE induced the ERK/JNK/p38/AMPKα1/2 signaling pathways; however, pretreatment with the corresponding inhibitors of MAPK or AMPK1/2 did not inhibit the CAPE effect on MALT1 blocking in PC-3 cells. Our findings verify that CAPE is an effective antitumor agent for human androgen-dependent and -independent prostate carcinoma cells in vitro and in vivo through the inhibition of MALT1 expression via the AR/p53/NF-κB signaling pathways. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/634826 | ISSN: | 2072-6694 | DOI: | 10.3390/cancers14020274 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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