標題: | Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population |
作者: | Shi, Jianxin Shiraishi, Kouya Choi, Jiyeon Matsuo, Keitaro Chen, Tzu-Yu Dai, Juncheng Hung, Rayjean J Chen, Kexin Shu, Xiao-Ou Kim, Young Tae Landi, Maria Teresa Chen, Kun-Chieh Gao, Yu-Tang Qian, Biyun Wu, Chen Lu, Daru Liu, Jianjun Schwartz, Ann G Houlston, Richard Spitz, Margaret R Gorlov, Ivan P Lin, Dongxin Wu, Xifeng Yang, Ping Lam, Stephen Tardon, Adonina Chen, Chu Bojesen, Stig E Johansson, Mattias Risch, Angela Bickeböller, Heike Ji, Bu-Tian Zheng, Wei Wichmann, H-Erich Christiani, David C Rennert, Gadi Arnold, Susanne Brennan, Paul McKay, James Field, John K Shete, Sanjay S Le Marchand, Loic Liu, Geoffrey Yin, Zhihua Andrew, Angeline Kiemeney, Lambertus A Zienolddiny-Narui, Shan Grankvist, Kjell Johansson, Mikael Cox, Angela Taylor, Fiona Yuan, Jian-Min Lazarus, Philip Schabath, Matthew B Zhou, Baosen Aldrich, Melinda C Jeon, Hyo-Sung Jiang, Shih Sheng Sung, Jae Sook Chen, Chung-Hsing Hsiao, Chin-Fu Jung, Yoo Jin Guo, Huan Hu, Zhibin Burdett, Laurie Song, Bao Yeager, Meredith Hutchinson, Amy Hicks, Belynda Liu, Jia Zhu, Bin Berndt, Sonja I Wu, Wei Wang, Junwen Li, Yuqing Choi, Jin Eun Wang, Jiucun Park, Kyong Hwa Sung, Sook Whan Liu, Li Kang, Chang Hyun Wang, Wen-Chang Xu, Jun Guan, Peng Tan, Wen CHONG-JEN YU Yang, Gong Seow, Wei Jie Sihoe, Alan Dart Loon Chen, Ying Choi, Yi Young Kim, Jun Suk Yoon, Ho-Il Park, In Kyu Xu, Ping He, Qincheng Wang, Chih-Liang Hung, Hsiao-Han Song, Lei Vermeulen, Roel C H Cheng, Iona Wu, Junjie Lim, Wei-Yen Tsai, Fang-Yu Chan, John K C Li, Jihua Chen, Hongyan Lin, Hsien-Chih Jin, Li Chang, I-Shou Liu, Jie Sawada, Norie Yamaji, Taiki Wyatt, Kathleen Li, Shengchao A Ma, Hongxia Zhu, Meng Wang, Zhehai Cheng, Sensen Li, Xuelian Hu, Wei Ren, Yangwu Chao, Ann Iwasaki, Motoki Zhu, Junjie Jiang, Gening Fei, Ke Wu, Guoping Chen Chih-Yi Chen, Chien-Jen PAN-CHYR YANG Chien, Li-Hsin Yu, Jinming Stevens, Victoria L Fraumeni, Joseph F Chatterjee, Nilanjan Gorlova, Olga Y Hsiung, Chao Agnes Amos, Christopher I Shen, Hongbing Chanock, Stephen J Rothman, Nathaniel Cai, Qiuyin Kohno, Takashi Lan, Qing Hong, Yun-Chul Kim, Hee Nam Wu, Yi-Long Wong, Maria Pik Richardson, Brian Douglas Funderburk, Karen M Li, Shilan Zhang, Tongwu Breeze, Charles Wang, Zhaoming Blechter, Batel Bassig, Bryan A Kim, Jin Hee Albanes, Demetrius Wong, Jason Y Y Shin, Min-Ho Chung, Lap Ping Yang, Yang An, She-Juan Zheng, Hong Yatabe, Yasushi Zhang, Xu-Chao Kim, Young-Chul Caporaso, Neil E Chang, Jiang Ho, James Chung Man Kubo, Michiaki Daigo, Yataro Song, Minsun Momozawa, Yukihide Kamatani, Yoichiro Kobayashi, Masashi Okubo, Kenichi Honda, Takayuki Hosgood, Dean H Kunitoh, Hideo Patel, Harsh Watanabe, Shun-Ichi Miyagi, Yohei Nakayama, Haruhiko Matsumoto, Shingo Horinouchi, Hidehito Tsuboi, Masahiro Hamamoto, Ryuji Goto, Koichi Ohe, Yuichiro Takahashi, Atsushi Goto, Akiteru Minamiya, Yoshihiro Hara, Megumi Nishida, Yuichiro Takeuchi, Kenji Wakai, Kenji Matsuda, Koichi Murakami, Yoshinori Shimizu, Kimihiro Suzuki, Hiroyuki Saito, Motonobu Ohtaki, Yoichi Tanaka, Kazumi Wu, Tangchun Wei, Fusheng Dai, Hongji Machiela, Mitchell J Su, Jian Kim, Yeul Hong Oh, In-Jae Lee, Victor Ho Fun Chang, Gee-Chen Tsai, Ying-Huang KUAN-YU CHEN Huang, Ming-Shyan Su, Wu-Chou Chen, Yuh-Min Seow, Adeline Park, Jae Yong Kweon, Sun-Seog |
公開日期: | 26-五月-2023 |
卷: | 14 |
期: | 1 |
來源出版物: | Nature communications |
摘要: | Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/634961 |
ISSN: | 2041-1723 |
DOI: | 10.1038/s41467-023-38196-z |
顯示於: | 醫學系
|