https://scholars.lib.ntu.edu.tw/handle/123456789/634997
標題: | Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression | 作者: | Tzeng, Yi-Shiuan Li, Hung Kang, Yuan-Lin Chen, Wen-Cheng Cheng, Wei-Cheng DAR-MING LAI |
公開日期: | 13-一月-2011 | 卷: | 117 | 期: | 2 | 來源出版物: | Blood | 摘要: | The C-X-C-type chemokine Cxcl12, also known as stromal cell-derived factor-1, plays a critical role in hematopoiesis during fetal development. However, the functional requirement of Cxcl12 in the adult hematopoietic stem/progenitor cell (HSPC) regulation was still unclear. In this report, we developed a murine Cxcl12 conditional deletion model in which the target gene can be deleted at the adult stage. We found that loss of stroma-secreted Cxcl12 in the adult led to expansion of the HSPC population as well as a reduction in long-term quiescent stem cells. In Cxcl12-deficient bone marrow, HSPCs were absent along the endosteal surface, and blood cell regeneration occurred predominantly in the perisinusoidal space after 5-fluorouracil myelosuppression challenge. Our results indicate that Cxcl12 is required for HSPC homeostasis regulation and is an important factor for osteoblastic niche organization in adult stage bone marrow. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/634997 | ISSN: | 00064971 | DOI: | 10.1182/blood-2010-01-266833 |
顯示於: | 醫學系 |
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