Methotrexate inhibition of SARS-CoV-2 entry, infection and inflammation revealed by bioinformatics approach and a hamster model
Journal
Frontiers in immunology
Journal Volume
13
Date Issued
2022
Author(s)
Chen, Yun-Ti
Chang, Yu-Hsiu
Pathak, Nikhil
Tzou, Shey-Cherng
Luo, Yong-Chun
Hsu, Yen-Chao
Li, Tian-Neng
Lee, Jung-Yu
Chen, Yi-Cyun
Huang, Yu-Wei
Yang, Hsin-Ju
Hsu, Nung-Yu
Tsai, Hui-Ping
Chang, Tein-Yao
Hsu, Shu-Chen
Liu, Ping-Cheng
Chin, Yuan-Fan
Lin, Wen-Chin
Yang, Chuen-Mi
Wu, Hsueh-Ling
Lee, Chia-Ying
Hsu, Hui-Ling
Liu, Yi-Chun
Chu, Jhih-Wei
Wang, Lily Hui-Ching
Huang, Chih-Heng
Lin, Chi-Hung
Hsieh, Po-Shiuan
Wu Lee, Yan-Hwa
Hung, Yi-Jen
Yang, Jinn-Moon
Abstract
Drug repurposing is a fast and effective way to develop drugs for an emerging disease such as COVID-19. The main challenges of effective drug repurposing are the discoveries of the right therapeutic targets and the right drugs for combating the disease.
Subjects
SARS-CoV-2; drug repurposing; inflammation; methotrexate; multi-target drugs
Type
journal article