https://scholars.lib.ntu.edu.tw/handle/123456789/635325
Title: | Options of Colorectal Cancer Screening: An Overview | Authors: | TSUNG-HSIEN CHIANG YI-CHIA LEE |
Keywords: | Colon capsule endoscopy | Colonoscopy | Colorectal cancer screening | Computed tomographic colonography | Fecal hemoglobin concentration | Fecal immunochemical test | Fecal microbiota | Flexible sigmoidoscopy | Guaiac-based fecal occult blood test | Plasmic methylated septin-9 | Stool DNA test | Issue Date: | 1-Jan-2020 | Start page/Pages: | 29 | Source: | Colorectal Cancer Screening: Theory and Practical Application | Abstract: | Colorectal cancer is not only a significant health issue in industrialized and developed countries; its incidence rate is also increasing in developing countries, making it the most prevalent cancer on a global scale. Given the limited effect of risk factor modification for primary prevention, secondary prevention—in the form of screening and early detection—is currently the most effective approach to reducing deaths from colorectal cancer through the use of colonoscopy. Nonetheless, colonoscopy itself is time-consuming, labor-intensive, and not without risk; also, the resource constraint of the limited number of endoscopists makes it not practical to serve as the primary screening tool in many countries. To enable better resource allocation, a two-stage approach is increasingly popular: first, a noninvasive screening test, then a confirmatory examination such as colonoscopy. Such an approach has two advantages: A higher participation rate when most of the target population is asymptomatic and better resource allocation when the screening test is highly accurate in identifying subjects with colorectal neoplasms. Several types of screening tests are available, including stool-based tests, such as the guaiac-based fecal occult blood test, the fecal immunochemical test, and the stool DNA test, and blood-based tests, such as the plasmic methylated septin-9 test. Even for the image-based tests, there are noninvasive tests, such as the computed tomographic colonography and colon capsule endoscopy, in addition to the invasive studies of flexible sigmoidoscopy and colonoscopy. Here, we present a precis of the performance and clinical application of these tests for mass screening. |
URI: | https://www.scopus.com/record/display.uri?eid=2-s2.0-85151681053&doi=10.1007%2f978-981-15-7482-5_3&origin=inward&txGid=ddc8635abdd5ee9104b2edc4dd8f432d https://scholars.lib.ntu.edu.tw/handle/123456789/635325 |
ISBN: | 9789811574825 | DOI: | 10.1007/978-981-15-7482-5_3 |
Appears in Collections: | 醫學系 |
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