A biocompatible needle-type glucose sensor based on platinum-electroplated carbon electrode
Journal
Applied biochemistry and biotechnology
Journal Volume
36
Journal Issue
3
Pages
211
Date Issued
1992-09
Author(s)
Abstract
A biocompatible needle-type glucose sensor with a 3-electrode configuration was constructed. A platinum-electroplated carbon stick was used as the working electrode, Ag/AgCl as the reference electrode, and a disposable hypodermic needle made of stainless steel as the counter electrode. A Nafion membrane, an immobilized glucose oxidase (GOD) membrane, and a biocompatible membrane with diffusion-limiting effect were coated successively onto the working electrode. The sensor showed a rapid response (< 120 s in batch operation), good reproducibility (RE < 3%), good stability (over 36 h in control serum), a wide dynamic range (5-600 mg/dL glucose), and superior biocompatibility. It was used to determine glucose in serum. The data obtained from the sensor showed good agreement with that from a clinical autoanalyzer (R > 0.95).
Subjects
2-methacryloyloxyethyl phosphorylcholine (MPC) | Biocompatibility | cellulose triacetate (CTA) | diffusion-limiting effect | glucose oxidase | glucose sensor | n-butylmethacrylate (BMA) | needle type | serum
Type
journal article