https://scholars.lib.ntu.edu.tw/handle/123456789/635431
標題: | Decipher the Immunopathological Mechanisms and Set Up Potential Therapeutic Strategies for Patients with Lupus Nephritis | 作者: | Tsai, Chang-Youh KO-JEN LI CHIEH-YU SHEN CHENG-HSUN LU Lee, Hui-Ting Wu, Tsai-Hung Ng, Yee-Yung Tsao, Yen-Po SONG-CHOU HSIEH CHIA-LI YU |
關鍵字: | NLRP3 inflammasome; anti-dsDNA antibodies; cross-reactivity; lupus nephritis; renal resident cells; type I interferon | 公開日期: | 13-六月-2023 | 出版社: | Multidisciplinary Digital Publishing Institute (MDPI) | 卷: | 24 | 期: | 12 | 來源出版物: | International journal of molecular sciences | 摘要: | Lupus nephritis (LN) is one of the most severe complications in patients with systemic lupus erythematosus (SLE). Traditionally, LN is regarded as an immune complex (IC) deposition disease led by dsDNA-anti-dsDNA-complement interactions in the subendothelial and/or subepithelial basement membrane of glomeruli to cause inflammation. The activated complements in the IC act as chemoattractants to chemically attract both innate and adaptive immune cells to the kidney tissues, causing inflammatory reactions. However, recent investigations have unveiled that not only the infiltrating immune-related cells, but resident kidney cells, including glomerular mesangial cells, podocytes, macrophage-like cells, tubular epithelial cells and endothelial cells, may also actively participate in the inflammatory and immunological reactions in the kidney. Furthermore, the adaptive immune cells that are infiltrated are genetically restricted to autoimmune predilection. The autoantibodies commonly found in SLE, including anti-dsDNA, are cross-reacting with not only a broad spectrum of chromatin substances, but also extracellular matrix components, including α-actinin, annexin II, laminin, collagen III and IV, and heparan sulfate proteoglycan. Besides, the glycosylation on the Fab portion of IgG anti-dsDNA antibodies can also affect the pathogenic properties of the autoantibodies in that α-2,6-sialylation alleviates, whereas fucosylation aggravates their nephritogenic activity. Some of the coexisting autoantibodies, including anti-cardiolipin, anti-C1q, anti-ribosomal P autoantibodies, may also enhance the pathogenic role of anti-dsDNA antibodies. In clinical practice, the identification of useful biomarkers for diagnosing, monitoring, and following up on LN is quite important for its treatments. The development of a more specific therapeutic strategy to target the pathogenic factors of LN is also critical. We will discuss these issues in detail in the present article. |
URI: | https://www.scopus.com/record/display.uri?eid=2-s2.0-85163962630&doi=10.3390%2fijms241210066&origin=inward&txGid=5ca382c23d9aa5858ae8da4658109538 https://scholars.lib.ntu.edu.tw/handle/123456789/635431 |
ISSN: | 16616596 | DOI: | 10.3390/ijms241210066 |
顯示於: | 醫學系 |
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