https://scholars.lib.ntu.edu.tw/handle/123456789/635445
標題: | Determination of o-phthalaldehyde for dose verification of the clinical disinfectant by fluorescent sequential injection analysis | 作者: | Chen, Hung Yu RICHIE CHEN PO-CHUAN HSIEH TZONG-JIH CHENG |
關鍵字: | Disinfectant | Fluorimetry | o-Phthalaldehyde (OPA) | Sequential injection analysis (SIA) | 公開日期: | 1-一月-2023 | 來源出版物: | Analytical Sciences | 摘要: | A new automated, generic analytical approach for determining the clinical disinfectant o-phthalaldehyde (OPA) is reported in this study. The proposed sequential injection analysis (SIA) is based on the online reaction of the OPA with glycine/N-acetylcysteine (NAC) in a neutral medium (pH = 7.0) to form a highly fluorescent isoindole derivative. All critical flow and reaction variables were investigated, while validation was carried out in the linearity detection range (0.0075–0.02%). As a result, excellent linearity (R 2 > 0.99) and precision (1.5–2.4% for repeatability and 0.7–2.2% for reproducibility) were achieved for the reference OPA solutions. Furthermore, reasonable concentration verification of OPA disinfection (0.2–0.6%) in healthcare institutes can be achieved using the developed fluorescent SIA due to its good sensitivity (0.111 V/%) and precision (1.0–2.3% for intermediate precision) around the minimum effective concentration (MEC) of 0.3% for Cidex-OPA disinfectant. Graphical abstract: [Figure not available: see fulltext.] |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85169154291&doi=10.1007%2fs44211-023-00415-4&partnerID=40&md5=e2fd085a89644fbd7dc0d693e8401b88 https://scholars.lib.ntu.edu.tw/handle/123456789/635445 |
ISSN: | 09106340 | DOI: | 10.1007/s44211-023-00415-4 |
顯示於: | 生物機電工程學系 |
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