https://scholars.lib.ntu.edu.tw/handle/123456789/635448
標題: | Quantifiable features of a tidal breathing phenotype in dogs with severe bronchomalacia diagnosed by bronchoscopy | 作者: | Lin, Chung Hui Johnson, Lynelle R. Chang, Wei Tao Lo, Pei Ying HUI-WEN CHEN HUEY-DONG WU |
關鍵字: | Bronchomalacia | bronchoscopy | dogs | functional phenotype | lower airway obstruction | pulmonary function test | spirometry | tidal breathing | 公開日期: | 1-一月-2023 | 卷: | 43 | 期: | 1 | 來源出版物: | Veterinary Quarterly | 摘要: | Dynamic lower airway obstruction is the primary component of canine bronchomalacia, but the ventilatory function remains underinvestigated. This prospective study analyzed tidal breathing characteristics in 28 dogs, comprising 14 with severe bronchomalacia diagnosed by bronchoscopy versus 14 without respiratory disease. Spirometry was conducted in all dogs. Bronchoscopy with bronchoalveolar lavage or brush under anesthesia was performed in 14 dogs with cough and expiratory effort. Severe bronchomalacia was defined by the severity of collapse and total number of bronchi affected. Ventilatory characteristics were compared between groups. Results revealed that dogs with severe bronchomalacia had lower minute volume (218 vs 338 mL/kg, p =.039) and greater expiratory-to-inspiratory time ratio (1.55 vs 1.35, p =.01) compared to control dogs. The tidal breathing pattern of dogs with bronchomalacia was different from that of normal dogs, and the pattern differed from the concave or flat expiratory curves typical of lower airway obstruction. Compared to control dogs, dogs with severe bronchomalacia had a significantly prolonged low-flow expiratory phase (p <.001) on the flow-time plot and a more exponential shape of the expiratory curve (p <.001) on the volume-time plot. Flow-time index ExpLF/Te (>0.14) and volume-time index Vt-AUCexp (≤31%) had a high ROC-AUC (1.00, 95% confidence interval 0.88 to 1.00) in predicting severe bronchomalacia. In conclusion, the tidal breathing pattern identified here indicates abnormal and complicated ventilatory mechanics in dogs with severe bronchomalacia. The role of this pulmonary functional phenotype should be investigated for disease progression and therapeutic monitoring in canine bronchomalacia. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85169679571&doi=10.1080%2f01652176.2023.2252518&partnerID=40&md5=d034360fa226bc466faccddd8332188c https://scholars.lib.ntu.edu.tw/handle/123456789/635448 |
ISSN: | 01652176 | DOI: | 10.1080/01652176.2023.2252518 |
顯示於: | 獸醫學系 |
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