https://scholars.lib.ntu.edu.tw/handle/123456789/635468
Title: | Impact of Vutrisiran on Quality of Life and Physical Function in Patients with Hereditary Transthyretin-Mediated Amyloidosis with Polyneuropathy | Authors: | Obici, Laura Ajroud-Driss, Senda Lin, Kon-Ping Berk, John L Gillmore, Julian D Kale, Parag Koike, Haruki Danese, David Aldinc, Emre Chen, Chongshu Vest, John Adams, David MING-JEN LEE HSUEH-WEN HSUEH LI-KAI TSAI JEN-JEN SU Chou, Hsi-Chieh CHI-CHAO CHAO SUNG-TSANG HSIEH |
Keywords: | ATTRv amyloidosis; Nutritional status; Physical function; Polyneuropathy; Quality of life; RNA interference; Vutrisiran; hATTR amyloidosis | Issue Date: | Oct-2023 | Journal Volume: | 12 | Journal Issue: | 5 | Start page/Pages: | 1759 | Source: | Neurology and therapy | Abstract: | Hereditary transthyretin (ATTRv; v for variant) amyloidosis, also known as hATTR amyloidosis, is a progressive and fatal disease associated with rapid deterioration of physical function and patients' quality of life (QOL). Vutrisiran, a subcutaneously administered RNA interference (RNAi) therapeutic that reduces hepatic production of transthyretin, was assessed in patients with ATTRv amyloidosis with polyneuropathy in the pivotal HELIOS-A study. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/635468 | ISSN: | 2193-8253 | DOI: | 10.1007/s40120-023-00522-4 |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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