https://scholars.lib.ntu.edu.tw/handle/123456789/635631
標題: | Ultrafast cell switching for recording cell surface transitions: New insights into epidermal growth factor receptor signalling | 作者: | YA-YU CHIANG West, Jonathan |
公開日期: | 21-三月-2013 | 卷: | 13 | 期: | 6 | 來源出版物: | Lab on a Chip | 摘要: | A pinched-flow deflection technology was developed for rapid single cell switching between biochemical microenvironments. Millisecond switching was used to stimulate and preserve epidermal growth factor receptor (EGFR) autophosphorylation transitions. Intramolecular phosphorylation initiates signal transduction, is silenced by phosphatase activity until EGFR dimerization enables intermolecular phosphorylation to initiate downstream signalling. © 2013 The Royal Society of Chemistry. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/635631 | ISSN: | 14730197 | DOI: | 10.1039/c3lc41297k |
顯示於: | 機械工程學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。