An adjustable modular continuous liquid-liquid extraction (MCLLE) micro-device with 3D coaxial flow
Journal
22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Journal Volume
4
ISBN
9781510897571
Date Issued
2018-01-01
Author(s)
Abstract
In the pharmaceutical industry, the biocatalysis technology plays an important role. The optimization of the downstream bioprocessing can effectively reduce the production time and cost. Microscale reactor has less diffusion distance that can facilitate the progress of production parameter optimization and use less materials. In this paper, we first time demonstrated a modular continuous liquid-liquid extraction (MCLLE) micro-device that can do the extraction with two incompatible phases at different flow rates for further investigation on compound transport phenomena, such as enzymatic conversion ofa-methylbenzylamine into acetophenone by ω-transaminase reaction.
Subjects
Continuous extraction | Laplace pressure | Liquid-liquid extraction
Type
conference paper