https://scholars.lib.ntu.edu.tw/handle/123456789/635645
標題: | In Vitro Microfluidics-based Blood-brain Barrier Model | 作者: | YA-YU CHIANG Tu, Kai Hong |
關鍵字: | BBB | Blood brain barrier | In vitro barrier model | MEMS | microfluidics | organs-on-chips | physical stimulus | shear stress | 公開日期: | 1-四月-2019 | 來源出版物: | Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019 | 摘要: | Organs-on-chips in vitro model is a micro engineering system that containing the microchannel structure and could replicate the tissue living condition in vivo. Its benefit is to construct the user-friendly platform for the further biological experiment. We demonstrate a low-cost 2D organ-on-chip model which mimic the blood brain barrier (BBB) tissue for further clinical experiment, such as the drug delivery and cytotoxicity threat. MEMS-fabricated wafer was used for the microchannel fabrication. The completely transparent material offered the advanced visibility for the researchers. The continuous medium supplement could mimic the hydrodynamic shear stress (SS) as the physical stimulus to the cell. We described the positive correlation between the shear stress and cell growing orientation. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/635645 | ISBN: | 9781728116297 | DOI: | 10.1109/NEMS.2019.8915667 |
顯示於: | 機械工程學系 |
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