Scale-out production in core-annular liquid–liquid microextractor
Journal
Journal of Flow Chemistry
Journal Volume
11
Journal Issue
3
Date Issued
2021-09-01
Author(s)
Abstract
In the miniaturization process, enhanced mass and heat transport enable the production of fine chemicals and pharmaceuticals; therefore, this process has become an attractive research field. The scale-out core-annular liquid–liquid microextractor can further enhance the mass and heat transfer because of its increased total liquids contact area. In the current study, one such microextractor was employed, and four stretchable helix wires were placed in parallel and square arrangements for the aqueous stream to maintain the aqueous and solvent solution volume ratio at 1:10; these wires were surrounded by an organic solvent to ensure a stable aqueous–organic contact interface. A scale-out core-annular liquid–liquid microextractor was applied in 10 vol% acetone–toluene extract as a robust screening tool for process development; it demonstrated > 90 % extraction efficiency within 10 min and > 3 ml/hr production rate. These scale-out strategies revealed that the effective surface area–volume ratio applied in this study was more than 6 m− 1 and substantially mitigated insufficient production.
Subjects
CALLME | Core‐annular flow | Liquid–liquid extraction | Parallel flow | Scale‐out
Type
journal article