https://scholars.lib.ntu.edu.tw/handle/123456789/635828
Title: | Plasma high-sensitivity C-reactive protein level is associated with impaired estimated glomerular filtration rate in hypertensives | Authors: | Shu, Hsu Shien YI-YUN TAI Chang, Kai Ting Chu, Chun Yuan Hsu, Po Chao Su, Ho Ming Lin, Tsung-Hsien Voon, Wen Chol Lai, Wen Ter Sheu, Sheng Hsiung |
Keywords: | C-reactive protein | Chronic kidney disease | Glomerular filtration rate | Hypertension | Inflammation | Issue Date: | 1-Mar-2015 | Journal Volume: | 31 | Journal Issue: | 2 | Source: | Acta Cardiologica Sinica | Abstract: | Background: Both inflammation and chronic kidney disease (CKD) are related to cardiovascular disease. Whether inflammatory biomarkers are associated with impaired glomerular filtration rate (GFR) is unclear in hypertensives. Methods: We recruited hypertension patients fromthe cardiovascular clinic of a tertiarymedical center in Taiwan. GFR was calculated using the 7-item Modification of Diet in Renal Disease (MDRD) study equation and impaired GFR (IGFR) was defined as GFR less than 60 ml/min/1.73 m2. High-sensitivity C-reactive protein (hsCRP) kits were used for the measurement of the CRP levels. Results: In our study, 572 consecutive hypertensive patients were enrolled. The range of patient age was 26-91 years (mean 60.5 ± 11.7), and hsCRP and GFR ranged from 0.01 to 9.99 mg/L and 16.6 to 239.6 ml/min//1.73 m2, respectively. HsCRP levels were correlated with GFR (p = 0.01) and the presence of IGFR (p = 0.009). Multivariate regression analysis showed hsCRP (p = 0.03), age (p < 0.001) and urinary albumin-to-creatinine ratio (UACR) (p = 0.002) are independent factors associated with GFR. Furthermore, hsCRP levels [odds ratio (OR) = 1.16, 95% CI = 1.03-1.31, p = 0.02], age (OR = 1.09, 95% CI = 1.07-1.12, p < 0.001), and UACR (OR = 1.02, 95% CI = 1.01-1.04, p < 0.001) independently predicted the presence of IGFR using binary logistic regression analysis. Conclusions: Information obtained from our study showed that hsCRP is associated with IGFR in hypertensives. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/635828 | ISSN: | 10116842 | DOI: | 10.6515/ACS20140630C |
Appears in Collections: | 醫學系 |
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