https://scholars.lib.ntu.edu.tw/handle/123456789/636441
Title: | Different risk factors between reflux symptoms and mucosal injury in gastroesophageal reflux disease | Authors: | Li, Chung-Hsien Hsieh, Tsung-Cheng Hsiao, Tsung-Hsien Wang, Pin-Chao TAI-CHUNG TSENG Lin, Hans Hsienhong Wang, Chia-Chi |
Keywords: | Gastroesophageal reflux disease; Nonerosive reflux disease; Reflux disease questionnaire; Risk factor | Issue Date: | Jun-2015 | Journal Volume: | 31 | Journal Issue: | 6 | Start page/Pages: | 320 | Source: | The Kaohsiung journal of medical sciences | Abstract: | Gastroesophageal reflux disease (GERD) is diagnosed based on typical symptoms in clinical practice. It can be divided into two groups using endoscopy: erosive and nonerosive reflux disease (NERD). This study aims to determine the risk factors of reflux symptoms and mucosal injury. This was a two-step case-control study derived from a cohort of 998 individuals having the data of reflux disease questionnaire (RDQ) and endoscopic findings. Those with minor reflux symptoms were excluded. The first step compared symptomatic GERD patients with healthy controls. The 2(nd) step compared patients with erosive esophagitis with healthy controls. In this study, the prevalence of symptomatic GERD and erosive esophagitis were 163 (16.3%) and 166 (16.6%), respectively. A total of 507 asymptomatic individuals without mucosal injury of the esophagus on endoscopy were selected as healthy controls. Compared with healthy controls, multivariate analyses showed that symptomatic GERD patients had a higher prevalence of hypertriglyceridemia [odds ratio (OR), 1.83; 95% confidence interval (CI) 1.13-2.96] and obesity (OR, 1.85; 95% CI 1.08-3.02). By contrast, male sex (OR, 2.24; 95% CI 1.42-3.52), positive Campylo-like organism (CLO) test (OR, 0.56; 95% CI 0.37-0.84), and hiatus hernia (OR, 14.36; 95% CI 3.05-67.6) were associated with erosive esophagitis. In conclusion, obesity and hypertriglyceridemia were associated with reflux symptoms. By contrast, male sex, negative infection of Helicobacter pylori, and hiatus hernia were associated with mucosal injury. Our results suggested that risk factors of reflux symptoms or mucosal injury might be different in GERD patients. The underlying mechanism awaits further studies to clarify. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84931563299&doi=10.1016%2fj.kjms.2015.02.007&partnerID=40&md5=8a0b8d3226115f059a95dcbdafc6a47f https://scholars.lib.ntu.edu.tw/handle/123456789/636441 |
ISSN: | 1607551X | DOI: | 10.1016/j.kjms.2015.02.007 |
Appears in Collections: | 醫學系 |
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