https://scholars.lib.ntu.edu.tw/handle/123456789/636446
標題: | Computational fluid dynamics study in children with obstructive sleep apnea | 作者: | WEI-CHUNG HSU Kun-Tai Kang ALEX YUNN-JY CHEN WEN-CHIN WENG PEI-LIN LEE Hung-Ta Hsiao |
關鍵字: | child;cone-beam computed tomography;pressure;resistance;sleep apnea syndromes;upper airway;velocity | 公開日期: | 2024 | 來源出版物: | Clinical Otolaryngology | 摘要: | Objectives: This study aims to identify characteristics in image-based computational fluid dynamics (CFD) in children with obstructive sleep apnea (OSA). Design: Diagnostic study. Setting: Hospital-based cohort. Participants: Children with symptoms suggestive of OSA were recruited and underwent polysomnography. Main outcome measures: Three-dimensional models of computational fluid dynamics were derived from cone-beam computed tomography. Results: A total of 68 children participated in the study (44 boys; mean age: 7.8 years), including 34 participants having moderate-to-severe OSA (apneahypopnea index [AHI] greater than 5 events/h), and 34 age, gender, and body mass index percentile matched participants having primary snoring (AHI less than 1). Children with moderate-to-severe OSA had a significantly higher total airway pressure (166.3 vs. 39.1 Pa, p = .009), total airway resistance (9851 vs. 2060 Newton-metre, p = .004) and velocity at a minimal cross-sectional area (65.7 vs. 8.8 metre per second, p = .017) than those with primary snoring. The optimal cut-off points for moderate-to-severe OSA were 46.2 Pa in the total airway pressure (area under the curve [AUC] = 73.2%), 2373 Newton-metre in the total airway resistance (AUC = 72.5%) and 12.6 metres per second in the velocity at a minimal crosssectional area (AUC = 70.5%). The conditional logistic regression model revealed that total airway pressure, total airway resistance and velocity at minimal cross-sectional area were significantly associated with an increased risk of moderate-to-severe OSA. Conclusions: This study demonstrates that CFD could be a useful tool for evaluating upper airway patency in children with OSA. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/636446 | DOI: | https://doi.org/10.1111/coa.14114 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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