https://scholars.lib.ntu.edu.tw/handle/123456789/636765
Title: | Unsatisfactory reproducibility of interstitial inflammation scoring in allograft kidney biopsy | Authors: | Huang, Shun-Chen Lin, Yi-Jia Wen, Mei-Chin WEI-CHOU LIN Fang, Pei-Wei Liang, Peir-In Chuang, Hao-Wen Chien, Hui-Ping Chen, Tai-Di |
Issue Date: | 1-May-2023 | Journal Volume: | 13 | Journal Issue: | 1 | Source: | Scientific reports | Abstract: | Interstitial inflammation scoring is incorporated into the Banff Classification of Renal Allograft Pathology and is essential for the diagnosis of T-cell mediated rejection. However, its reproducibility, including inter-rater and intra-rater reliabilities, has not been carefully investigated. In this study, eight renal pathologists from different hospitals independently scored 45 kidney allograft biopsies with varying extents of interstitial inflammation. Inter-rater reliabilities and intra-rater reliabilities were investigated by kappa statistics and conditional agreement probabilities. Individual pathologists' scoring patterns were examined by chi-squared tests and proportions tests. The mean pairwise kappa values for inter-rater reliability were 0.27, 0.30, and 0.26 for the Banff i score, ti score, and i-IFTA, respectively. No rater pair performed consistently better or worse than others on all three scorings. After dichotomizing the scores into two groups (none/mild and moderate/severe inflammation), the averaged conditional agreements ranged from 47.1% to 50.0%. The distributions of the scores differed, but some pathologists persistently scored higher or lower than others. Given the important role of interstitial inflammation scoring in the diagnosis of T-cell mediated rejection, transplant practitioners should be aware of the possible clinical implications of the far-from-optimal reproducibility. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/636765 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-023-33908-3 |
Appears in Collections: | 病理學科所 |
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