https://scholars.lib.ntu.edu.tw/handle/123456789/636992
Title: | Deep learning-based photodamage reduction on harmonic generation microscope at low-level optical power | Authors: | Shen, Yi Jiun Liao, En Yu Tai, Tsung Ming YI-HUA LIAO CHI-KUANG SUN Lee, Cheng Kuang See, Simon Chen, Hung Wen |
Keywords: | deep learning | harmonic generation microscope (HGM) | nonlinear optics | photodamage | phototoxicity | Issue Date: | 1-Jan-2023 | Source: | Journal of Biophotonics | Abstract: | The trade-off between high-quality images and cellular health in optical bioimaging is a crucial problem. We demonstrated a deep-learning-based power-enhancement (PE) model in a harmonic generation microscope (HGM), including second harmonic generation (SHG) and third harmonic generation (THG). Our model can predict high-power HGM images from low-power images, greatly reducing the risk of phototoxicity and photodamage. Furthermore, the PE model trained only on normal skin data can also be used to predict abnormal skin data, enabling the dermatopathologist to successfully identify and label cancer cells. The PE model shows potential for in-vivo and ex-vivo HGM imaging. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/636992 | ISSN: | 1864063X | DOI: | 10.1002/jbio.202300285 |
Appears in Collections: | 電機工程學系 |
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