https://scholars.lib.ntu.edu.tw/handle/123456789/637022
標題: | Hair Follicle Transit-Amplifying Cells Phagocytose Dead Cells after Radiotherapeutic and Chemotherapeutic Injuries for Timely Regeneration | 作者: | JIN-BON HONG Wang, Wei-Hung Hsu, Yao-Wen Tee, Suet Yee Wu, Yueh-Feng Huang, Wen-Yen SHIH-FAN LAI Lin, Sung-Jan |
公開日期: | 19-八月-2023 | 來源出版物: | The Journal of investigative dermatology | 摘要: | Efficient clearance of dead cells is critical for tissue regeneration after injuries. How dead cells are removed from the skin after radiotherapy and chemotherapy is unclear. In this study, we found that radiotherapeutic and chemotherapeutic damage induced extensive apoptosis of highly proliferative transit-amplifying cells in hair follicles. These apoptotic cells disappeared rapidly in the early stage of regenerative attempts, and the lost structures were regenerated with transient and low-level inflammation. Without the recruitment of macrophages as scavengers, the dying cells were engulfed directly by adjacent surviving transit-amplifying cells, which produced mature phagosomes through fusion with lysosomes in a manner similar to professional phagocytosis and remained active in proliferation. Autophagy did not contribute significantly to the clearance of engulfed cell debris. Perturbing phagocytosis in the transit-amplifying cells hindered apoptotic cell removal, delayed structural recovery, and aggravated hair loss. Therefore, transit-amplifying cells are capacitated with both proliferative and efferocytic functions that facilitate tissue regeneration after tissue injury. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637022 | ISSN: | 0022202X | DOI: | 10.1016/j.jid.2023.07.012 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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