https://scholars.lib.ntu.edu.tw/handle/123456789/637033
標題: | The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients | 作者: | Hsu, Chia-Jui LEE-CHIN WONG Wang, Hsin-Pei Chung, Yi-Chun Kao, Te-Wei Weng, Chen-Hsiang WEN-CHAU WU STEVEN SHINN-FORNG PENG WEN-YIH TSENG WANG-TSO LEE |
關鍵字: | Diffusion spectrum imaging; False discovery rate; Frontostriatal; Gilles de la Tourette syndrome; Pediatric neurology | 公開日期: | 25-十月-2023 | 卷: | 15 | 期: | 1 | 來源出版物: | Journal of neurodevelopmental disorders | 摘要: | Gilles de la Tourette syndrome (GTS) is a prevalent pediatric neurological disorder. Most studies point to abnormalities in the cortico-striato-thalamocortical (CSTC) circuits. Neuroimaging studies have shown GTS's extensive impact on the entire brain. However, due to participant variability and potential drug and comorbidity impact, the results are inconsistent. To mitigate the potential impact of participant heterogeneity, we excluded individuals with comorbidities or those currently undergoing medication treatments. Based on the hypothesis of abnormality within the CSTC circuit, we investigated microstructural changes in white matter using diffusion spectrum imaging (DSI). This study offers the first examination of microstructural changes in treatment-naïve pediatric patients with pure GTS using diffusion spectrum imaging. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637033 | ISSN: | 18661947 | DOI: | 10.1186/s11689-023-09501-0 |
顯示於: | 醫學系 |
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