https://scholars.lib.ntu.edu.tw/handle/123456789/637165
標題: | Immune responses and safety of COVID-19 vaccination in atypical hemolytic uremic syndrome patients in Taiwan | 作者: | Chen, I-Ru Wang, Guei-Jane PO-REN HSUEH Chou, Chia-Hui Jeng, Long-Bin Lin, Hui-Ju Liao, Huang-Jiun Lai, Ping-Chin Chang, Jan-Gowth Huang, Chiu-Ching |
關鍵字: | Atypical hemolytic uremic syndrome; COVID-19; Vaccination | 公開日期: | 22-九月-2023 | 卷: | 41 | 期: | 41 | 來源出版物: | Vaccine | 摘要: | Atypical hemolytic uremic syndrome is a rare, life-threatening disorder which can be triggered by COVID 19 infection and COVID 19 vaccination then induce multiple organ failure. Our study is the first to evaluate immune responses to COVID-19 vaccination and safety in a cohort of patients in a local single-center study in Taiwan.. Results indicate that vaccines effectively shield aHUS patients from severe COVID-19 complications without significant safety concerns. A double booster dose for the third vaccine is essential for optimal efficacy. Anti-complement therapy did not influence vaccination effectiveness. Transplant aHUS patients had the lowest immune response titers, indicating a need for additional vaccine doses. Compared to healthcare workers, aHUS patients had poor T-cell responses. We noted a superior trend with mixed-type COVID-19 vaccinations in aHUS patients, while fixed-type mRNA demonstrated better results in healthcare workers. Our findings endorse COVID-19 vaccination as a potent strategy to safeguard aHUS patients from severe complications, emphasizing the importance of vigilant monitoring pre- and post-vaccination. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637165 | ISSN: | 0264410X | DOI: | 10.1016/j.vaccine.2023.08.020 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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