https://scholars.lib.ntu.edu.tw/handle/123456789/637174
標題: | Multiple impacts of Naa10p on cancer progression: Molecular functions and clinical prospects | 作者: | Ho, Kuo-Hao Pan, Ke-Fan TSU-YAO CHENG Chien, Ming-Hsien KUO-TAI HUA |
關鍵字: | Acetyltransferase; Cancer; Metastasis; Naa10p; Proliferation | 公開日期: | 31-八月-2023 | 出版社: | Elsevier B.V. | 卷: | 1878 | 期: | 6 | 來源出版物: | Biochimica et biophysica acta. Reviews on cancer | 摘要: | Nα-acetyltransferase 10 protein (Naa10p) is known as the catalytic subunit of N-terminal acetyltransferases A (NatA) complex, associating with Naa15p to acetylate N-termini of the human proteome. Recent investigations have unveiled additional functions for Naa10p, encompassing lysine ε-acetylation and acetyltransferase-independent activities. Its pleiotropic roles have been implicated in diverse physiological and pathological contexts. Emerging evidence has implicated Naa10p in cancer progression, demonstrating dual attributes as an oncogene or a tumor suppressor contingent on the cancer type and acetyltransferase activity context. In this comprehensive review, we present a pan-cancer analysis aimed at elucidating the intricacies underlying Naa10p dysregulation in cancer. Our findings propose the potential involvement of c-Myc as a modulatory factor influencing Naa10p expression. Moreover, we provide a consolidated summary of recent advancements in understanding the intricate molecular underpinnings through which Naa10p contributes to cancer cell proliferation and metastasis. Furthermore, we delve into the multifaceted nature of Naa10p's roles in regulating cancer behaviors, potentially attributed to its interactions with a repertoire of partner proteins. Through an exhaustive exploration of Naa10p's functions, spanning its acetylation activity and acetyltransferase-independent functionalities, this review offers novel insights with implications for targeted therapeutic strategies involving this pivotal protein in the realm of cancer therapeutics. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/637174 | ISSN: | 0304419X | DOI: | 10.1016/j.bbcan.2023.188973 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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